BDBM242940 US9422277, 3

SMILES CN1\C(N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1ncc([nH]1)-c1ccccn1)=N/C(=O)OC(C)(C)C

InChI Key

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 242940   

TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM242940(US9422277, 3)
Affinity DataKi:  87.9nM ΔG°:  -9.78kcal/molepH: 5.0 T: 2°CAssay Description:Inhibitor compounds, prepared at 3× the desired final concentration in 1×BACE assay buffer (20 mM sodium acetate pH 5.0, 10% glycerol, 0....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM242940(US9422277, 3)
Affinity DataKi:  470nM ΔG°:  -8.77kcal/molepH: 5.0 T: 2°CAssay Description:Varying concentrations of inhibitors at 3× the final desired concentration in a volume of 10 ul are preincubated with purified human BACE1 cata...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent