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BDBM243209 (s)-5,5-dimethyl-n-(piperidin-3-yl)-2-((tetrahydro-2h-pyran-4-yl)amino)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide::US9546173, cmpd 6

SMILES: CC1(C)N(Cc2nc(NC3CCOCC3)ncc12)C(=O)N[C@H]1CCCNC1

InChI Key: InChIKey=PLTPLCWQVRQNQA-AWEZNQCLSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 243209   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM243209
PNG
((s)-5,5-dimethyl-n-(piperidin-3-yl)-2-((tetrahydro...)
Show SMILES CC1(C)N(Cc2nc(NC3CCOCC3)ncc12)C(=O)N[C@H]1CCCNC1
Show InChI InChI=1S/C19H30N6O2/c1-19(2)15-11-21-17(22-13-5-8-27-9-6-13)24-16(15)12-25(19)18(26)23-14-4-3-7-20-10-14/h11,13-14,20H,3-10,12H2,1-2H3,(H,23,26)(H,21,22,24)/t14-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.34E+3n/an/an/an/a7.5n/a



Novartis AG

US Patent


Assay Description
Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...


US Patent US9546173 (2017)

More data for this
Ligand-Target Pair