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BDBM243239 5,5-dimethyl-n-(1-phenylcyclopropyl)-2-((tetrahydro-2h-pyran-4-yl)amino)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide::US9546173, cmpd 36

SMILES: CC1(C)N(Cc2nc(NC3CCOCC3)ncc12)C(=O)NC1(CC1)c1ccccc1

InChI Key: InChIKey=RKXJUDBWMJKFMM-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 243239   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM243239
PNG
(5,5-dimethyl-n-(1-phenylcyclopropyl)-2-((tetrahydr...)
Show SMILES CC1(C)N(Cc2nc(NC3CCOCC3)ncc12)C(=O)NC1(CC1)c1ccccc1
Show InChI InChI=1S/C23H29N5O2/c1-22(2)18-14-24-20(25-17-8-12-30-13-9-17)26-19(18)15-28(22)21(29)27-23(10-11-23)16-6-4-3-5-7-16/h3-7,14,17H,8-13,15H2,1-2H3,(H,27,29)(H,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 17n/an/an/an/a7.5n/a



Novartis AG

US Patent


Assay Description
Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...


US Patent US9546173 (2017)

More data for this
Ligand-Target Pair