BDBM243432 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(6-methoxy-1-methyl-1,2,3,4-tetrahydroquinolin-7-yl)pyrimidine-2,4-diamine::US10053458, 46

SMILES COc1cc2CCNC(C)c2cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1

InChI Key InChIKey=ZYGUBIXTHJEWAH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 243432   

TargetALK tyrosine kinase receptor [L1196M](Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

US Patent
LigandPNGBDBM243432(5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(6-me...)
Affinity DataIC50:  1.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

US Patent
LigandPNGBDBM243432(5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(6-me...)
Affinity DataIC50: <10nMT: 2°CAssay Description:A proliferation inhibitory activity against the ALK of the compound represented by Chemical Formula 1 according to the present invention at an enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent