BDBM24483 5-(3-{[(7-methoxyquinolin-4-yl)oxy]methyl}-[1,2,4]triazolo[4,3-a]pyridazin-6-yl)-3-methyl-1,2-thiazole::Triazolopyridazine, 10m::US9066954, 222

SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3cc(C)ns3)ccnc2c1

InChI Key InChIKey=DQDNVYJAOVRUOQ-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 24483   

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM24483(5-(3-{[(7-methoxyquinolin-4-yl)oxy]methyl}-[1,2,4]...)
Affinity DataKi:  1.60nM ΔG°:  -12.1kcal/molepH: 8.0 T: 2°CAssay Description:A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM24483(5-(3-{[(7-methoxyquinolin-4-yl)oxy]methyl}-[1,2,4]...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM24483(5-(3-{[(7-methoxyquinolin-4-yl)oxy]methyl}-[1,2,4]...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM24483(5-(3-{[(7-methoxyquinolin-4-yl)oxy]methyl}-[1,2,4]...)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of human CYP3A4 in human liver microsomes preincubated with NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM24483(5-(3-{[(7-methoxyquinolin-4-yl)oxy]methyl}-[1,2,4]...)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM24483(5-(3-{[(7-methoxyquinolin-4-yl)oxy]methyl}-[1,2,4]...)
Affinity DataIC50:  3nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed