BDBM246 US10201527, Compound 43::US10736881, Compound 43::US8551988, 43

SMILES CCn1c(C)nc2cc(\C=C\C(=O)NO)ccc12

InChI Key InChIKey=XSLXTSUEIOVWIS-FNORWQNLSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 246   

TargetHistone deacetylase 8(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM246(US10201527, Compound 43 | US10736881, Compound 43 ...)
Affinity DataIC50:  192nMAssay Description:The assay have been carried out in a 96 well format and the BIOMOL using a fluorescent-based HDAC activity assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM246(US10201527, Compound 43 | US10736881, Compound 43 ...)
Affinity DataIC50:  947nMAssay Description:The assay have been carried out in a 96 well format and the BIOMOL using a fluorescent-based HDAC activity assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM246(US10201527, Compound 43 | US10736881, Compound 43 ...)
Affinity DataIC50:  192nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM246(US10201527, Compound 43 | US10736881, Compound 43 ...)
Affinity DataIC50:  192nMAssay Description:To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5×105 cells/well for 24 h. Colo20...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM246(US10201527, Compound 43 | US10736881, Compound 43 ...)
Affinity DataIC50:  947nMAssay Description:The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM246(US10201527, Compound 43 | US10736881, Compound 43 ...)
Affinity DataIC50:  947nMAssay Description:The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...More data for this Ligand-Target Pair
In DepthDetails US Patent