BDBM247611 US9434719, 213::US9434719, 213 as TFA salt
SMILES C[C@@H](O)C1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1
InChI Key InChIKey=IPBYIAIAZKELOY-FEBOZLGHSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 247611
Affinity DataIC50: 11nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMpH: 7.4 T: 2°CAssay Description:The biochemical reactions were performed at room temperature in 384-well Greiner flat-bottom plates (Costar, Cat. No. 781201) using a final reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: <22.9nMpH: 7.4 T: 2°CAssay Description:The biochemical reactions were performed at room temperature in 384-well Greiner flat-bottom plates (Costar, Cat. No. 781201) using a final reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair