BDBM24777 5-hydroxy-1,4-dihydronaphthalene-1,4-dione::5-hydroxy-1,4-naphthoquinone, 4::CHEMBL43612::Juglone::Juglone (6a)
SMILES Oc1cccc2C(=O)C=CC(=O)c12
InChI Key InChIKey=KQPYUDDGWXQXHS-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 24 hits for monomerid = 24777 Sort by
Affinity DataIC50: 1.00E+3nMpH: 6.5 T: 37°CAssay Description:The IC50 inhibition assays were performed in a 96-well microtiter plate format using purified recombinant IDO, which was added to the substrate, L-tr...More data for this Ligand-Target Pair
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of human recombinant ERp72 assessed as inhibition of E-GSH formation using Di-E-GSSG as substrate measured for 60 mins in presence of DTT ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.36E+3nMAssay Description:The protocol for measuring IC50 values for the inhibition of MAO-A and MAO-B has been reported in detail in a recent publication (26). The recombinan...More data for this Ligand-Target Pair
Target3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ [1-175](Yersinia pestis)
Brookhaven National Laboratory
Brookhaven National Laboratory
Affinity DataIC50: 5.30E+3nMpH: 7.0 T: 25°CAssay Description:The enzymatic activities of FtFabZ and YpFabZ were determined via the reportedspectrophotometric method using the substrate analogue crotonoyl-CoA.7 ...More data for this Ligand-Target Pair
Target3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ(Francisella tularensis)
Brookhaven National Laboratory
Brookhaven National Laboratory
Affinity DataIC50: 5.40E+3nMpH: 7.0 T: 25°CAssay Description:The enzymatic activities of FtFabZ and YpFabZ were determined via the reportedspectrophotometric method using the substrate analogue crotonoyl-CoA.7 ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+4nMAssay Description:5-LO inhibitory activity was determined by inhibition of LTB4 biosynthesis in bovine polymorphonuclear leukocytes (PMNL)More data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase NIMA-interacting 1(Human)
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.01E+4nMAssay Description:Inhibition of Pin1 (unknown origin) using Suc-Ala-Glu-Pro-Phe-4-nitroanilide as substrate after 30 mins by protease-coupled assayMore data for this Ligand-Target Pair
TargetM-phase inducer phosphatase 2(Human)
Virginia Polytechnic Institute and State University
Curated by ChEMBL
Virginia Polytechnic Institute and State University
Curated by ChEMBL
Affinity DataIC50: 1.98E+3nMAssay Description:Inhibition of histidine-tagged human recombinant Cdc25B catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetDual specificity protein phosphatase 6(Rat)
Virginia Polytechnic Institute and State University
Curated by ChEMBL
Virginia Polytechnic Institute and State University
Curated by ChEMBL
Affinity DataIC50: 1.24E+4nMAssay Description:Inhibition of histidine-tagged rat recombinant MKP3 catalytic domain expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
TargetDual specificity protein phosphatase 1(Mouse)
Virginia Polytechnic Institute and State University
Curated by ChEMBL
Virginia Polytechnic Institute and State University
Curated by ChEMBL
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of histidine-tagged mouse MKP1 catalytic domain expressed in human Hela cellsMore data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase NIMA-interacting 1(Human)
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.08E+4nMAssay Description:Inhibition of Pin1 (unknown origin) assessed as reduction in peptidyl-prolyl isomerase activity incubated for 30 mins using Suc-Ala-Glu-cis-Pro-Phe-4...More data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase NIMA-interacting 1(Human)
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of human N-terminal His6-tagged Pin1 PPIase activity expressed in Escherichia coli BL21 using Suc-Ala-Glu-cis-Pro-Phe-4-nitroanilide as su...More data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase NIMA-interacting 1(Human)
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant N-terminal His6-tagged human Pin1 using Suc-Ala-Glu-cis-Pro-Phe-4-nitroanilide as substrate preincubated for 30 mins follow...More data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase NIMA-interacting 1(Human)
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.08E+4nMAssay Description:Inhibition of recombinant human Pin1 (Met1 to Glu163 residues) expressed in Escherichia coli using Suc-Ala-Glu-cis-Pro-Phe-4-nitroanilide as substrat...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Universit£T Leipzig
Curated by ChEMBL
Universit£T Leipzig
Curated by ChEMBL
Affinity DataEC50: 1.70E+3nMAssay Description:Activation of human TRPA1 expressed in HEK293 cells assessed as increase in calcium level by fluo-4 dye based plate reader analysisMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Universit£T Leipzig
Curated by ChEMBL
Universit£T Leipzig
Curated by ChEMBL
Affinity DataEC50: 1.70E+3nMAssay Description:Activation of human TRPA1 expressed in HEK293 cells assessed as increase in calcium level by fluo-4 dye based plate reader analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 8.26E+3nMAssay Description:Inhibition of DNA topoisomerase 1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 620nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase NIMA-interacting 1(Human)
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human Pin1 using Suc-AEPF-NH-Np as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 630nMAssay Description:Inhibition of PDI in human platelets assessed as inhibition of E-GSH formation using Di-E-GSSG as substrate measured for 60 mins in presence of DTT b...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant PDI assessed as inhibition of E-GSH formation using Di-E-GSSG as substrate measured for 60 mins in presence of DTT by...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human recombinant ERp57 assessed as inhibition of E-GSH formation using Di-E-GSSG as substrate measured for 60 mins in presence of DTT ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.71E+3nMAssay Description:The protocol for measuring IC50 values for the inhibition of MAO-A and MAO-B has been reported in detail in a recent publication (26). The recombinan...More data for this Ligand-Target Pair