BDBM248998 US9434725, 229::US9434725, 231

SMILES Cn1cc(cn1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCNCC(O)C1

InChI Key InChIKey=WHGGAJVOOZRMSO-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 248998   

TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM248998(US9434725, 229 | US9434725, 231)
Affinity DataKi:  0.0320nM ΔG°:  -14.3kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM248998(US9434725, 229 | US9434725, 231)
Affinity DataKi:  0.0780nM ΔG°:  -13.8kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM248998(US9434725, 229 | US9434725, 231)
Affinity DataKi:  0.131nM ΔG°:  -13.5kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM248998(US9434725, 229 | US9434725, 231)
Affinity DataKi:  0.316nM ΔG°:  -13.0kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM248998(US9434725, 229 | US9434725, 231)
Affinity DataKi:  1.39nM ΔG°:  -12.1kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM248998(US9434725, 229 | US9434725, 231)
Affinity DataKi:  9.39nM ΔG°:  -10.9kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent