BDBM249312 US10017501, Compound 1020-257::US9458145, 1020-257

SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ncccn1)c1ccc(F)cc1F

InChI Key

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 249312   

TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM249312(US10017501, Compound 1020-257 | US9458145, 1020-25...)
Affinity DataKi:  4.70nMAssay Description:Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [368-440](Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM249312(US10017501, Compound 1020-257 | US9458145, 1020-25...)
Affinity DataKi:  5.60nMAssay Description:Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM249312(US10017501, Compound 1020-257 | US9458145, 1020-25...)
Affinity DataIC50:  4.70nMpH: 7.5 T: 2°CAssay Description:The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [368-440](Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM249312(US10017501, Compound 1020-257 | US9458145, 1020-25...)
Affinity DataIC50:  5.60nMpH: 7.5 T: 2°CAssay Description:The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent