BDBM249413 US10537571, Compound 130::US10912774, Compound 130::US9434697, 130::US9730931, Compound 130
SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2ccccc2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
InChI Key InChIKey=XPADWPKAVAOLCN-UHFFFAOYSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 249413
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4° C., or for 1 hour at room temperature. Following pre-incubatio...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ I...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ ID NO:1) (20 μ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ ID NO:1) (20 μ...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ I...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...More data for this Ligand-Target Pair