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BDBM250453 US9464044, 50

SMILES: Cn1ccc2cccc(c12)S(=O)(=O)NC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O

InChI Key: InChIKey=GOPKEBWCYKQUGB-ZELUUWDMSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 250453   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250453
PNG
(US9464044, 50)
Show SMILES Cn1ccc2cccc(c12)S(=O)(=O)NC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O
Show InChI InChI=1S/C24H30N4O4S/c1-28-8-5-15-3-2-4-18(20(15)28)33(31,32)27-24(6-7-24)22(30)26-19-16-9-14-10-17(19)13-23(11-14,12-16)21(25)29/h2-5,8,14,16-17,19,27H,6-7,9-13H2,1H3,(H2,25,29)(H,26,30)/t14?,16?,17?,19-,23?
PDB
MMDB

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PC cid
PC sid
UniChem
n/an/a 0.400n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


US Patent US9464044 (2016)


BindingDB Entry DOI: 10.7270/Q2SJ1JH0
More data for this
Ligand-Target Pair