BDBM251460 US9452998, 9
SMILES CC1(N)CCN(CC1)c1cccnc1NC(=O)c1nc(cnc1N)-c1ncccc1C(F)(F)F
InChI Key InChIKey=XXJXHXJWQSCNPX-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 251460
Affinity DataIC50: 1.90nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of PKC-alpha (unknown origin)More data for this Ligand-Target Pair
TargetBifunctional peptidase and (3S)-lysyl hydroxylase JMJD7(Homo sapiens)
Sichuan University
Curated by ChEMBL
Sichuan University
Curated by ChEMBL
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of N-terminal His-tagged human JMJD7 (1 to 316 residues) expressed in Escherichia coli BL21 (DE3) luciferase based succinate-gloTM JmjC de...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PKA-theta (unknown origin) using Fam-labelled S6-derived peptide incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+3nMpH: 7.0 T: 2°CAssay Description:Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...More data for this Ligand-Target Pair