BDBM25265 (1-hydroxy-1-phosphonononyl)phosphonic acid::CHEMBL110971::bisphosphonate, 4

SMILES CCCCCCCCC(O)(P(O)(O)=O)P(O)(O)=O

InChI Key InChIKey=COHUUYPEYRMWTH-UHFFFAOYSA-N

Data  1 KI  4 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 25265   

TargetFarnesyl pyrophosphate synthase(Human)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM25265((1-hydroxy-1-phosphonononyl)phosphonic acid | CHEM...)
Affinity DataKi:  590nMAssay Description:Binding affinity of the compound towards T. cruzi farnesyl pyrophosphate synthase (TcFPPS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Human)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM25265((1-hydroxy-1-phosphonononyl)phosphonic acid | CHEM...)
Affinity DataIC50:  8.45E+3nMAssay Description:Binding affinity of the compound towards T. cruzi farnesyl pyrophosphate synthase (TcFPPS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Human)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM25265((1-hydroxy-1-phosphonononyl)phosphonic acid | CHEM...)
Affinity DataIC50:  4.54E+3nMAssay Description:Binding affinity of the compound towards T. cruzi farnesyl pyrophosphate synthase (TcFPPS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
National Taiwan University

LigandPNGBDBM25265((1-hydroxy-1-phosphonononyl)phosphonic acid | CHEM...)
Affinity DataIC50:  710nMpH: 7.0 T: 37°CAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetH(+)-exporting diphosphatase(Trypanosoma brucei)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25265((1-hydroxy-1-phosphonononyl)phosphonic acid | CHEM...)
Affinity DataIC50:  4.77E+4nMAssay Description:Inhibition of recombinant Trypanosoma brucei soluble vacuolar pyrophosphatase expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed