BDBM25297 1-(2-hydrogen phosphonato-2-hydroxy-2-phosphonoethyl)-3-(3-phenylphenyl)pyridin-1-ium::CHEMBL192017::bisphosphonate, 7

SMILES OC(C[n+]1cccc(c1)-c1cccc(c1)-c1ccccc1)(P(O)(O)=O)P(O)([O-])=O

InChI Key InChIKey=SFGYQDTXSJEVCC-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 25297   

TargetGeranylgeranyl pyrophosphate synthase BTS1(Saccharomyces cerevisiae (Yeast))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25297(1-(2-hydrogen phosphonato-2-hydroxy-2-phosphonoeth...)
Affinity DataKi:  10nMAssay Description:Binding affinity to Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25297(1-(2-hydrogen phosphonato-2-hydroxy-2-phosphonoeth...)
Affinity DataKi:  230nMAssay Description:Binding affinity to human GGPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyprenyl synthetase family protein(Plasmodium falciparum (isolate 3D7))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25297(1-(2-hydrogen phosphonato-2-hydroxy-2-phosphonoeth...)
Affinity DataKi:  950nMAssay Description:Binding affinity towards Farnesyl diphosphate synthase from leishmania majorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25297(1-(2-hydrogen phosphonato-2-hydroxy-2-phosphonoeth...)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibition of human GGPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25297(1-(2-hydrogen phosphonato-2-hydroxy-2-phosphonoeth...)
Affinity DataIC50:  1.12E+4nMAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase BTS1(Saccharomyces cerevisiae (Yeast))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25297(1-(2-hydrogen phosphonato-2-hydroxy-2-phosphonoeth...)
Affinity DataIC50:  30nMAssay Description:Inhibition of Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed