BDBM25380 1,7-dibenzyl-8-{[(2E)-3-chlorobut-2-en-1-yl]sulfanyl}-3-methyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione::purine-2,6-dione, 23

SMILES C\C(Cl)=C/CSc1nc2n(C)c(=O)n(Cc3ccccc3)c(=O)c2n1Cc1ccccc1

InChI Key InChIKey=ILBOKBKKRWRYIJ-GHRIWEEISA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25380   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University Of Pennsylvania

LigandPNGBDBM25380(1,7-dibenzyl-8-{[(2E)-3-chlorobut-2-en-1-yl]sulfan...)
Affinity DataIC50:  1.09E+4nMpH: 7.0 T: 2°CAssay Description:BRAF kinase activity was quantified using an ELISA-based MEK phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curve f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed