BDBM25450 4-[5-(pyridin-4-yl)-7,8-dihydronaphthalen-2-yl]benzene-1,2-diol::Abiraterone mimetic, 13

SMILES Oc1ccc(cc1O)-c1ccc2C(=CCCc2c1)c1ccncc1

InChI Key InChIKey=CLHXFMXKUDGILL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 25450   

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM25450(4-[5-(pyridin-4-yl)-7,8-dihydronaphthalen-2-yl]ben...)
Affinity DataIC50:  307nMpH: 7.4 T: 2°CAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Saarland University

LigandPNGBDBM25450(4-[5-(pyridin-4-yl)-7,8-dihydronaphthalen-2-yl]ben...)
Affinity DataIC50:  357nMAssay Description:To measure CYP3A4 activity, the product of testosterone 6-hydroxylation, 6beta-hydroxytestosterone was determined. After incubation, the reaction was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM25450(4-[5-(pyridin-4-yl)-7,8-dihydronaphthalen-2-yl]ben...)
Affinity DataIC50:  1.49E+3nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM25450(4-[5-(pyridin-4-yl)-7,8-dihydronaphthalen-2-yl]ben...)
Affinity DataIC50: >1.00E+4nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed