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BDBM254914 US9493483, 402

SMILES: CN(C)C(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(ccc2-c2c(C)noc12)-c1cnn(C)c1

InChI Key: InChIKey=RXXOWAAYINDZRV-QFIPXVFZSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 254914   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 4 Bromo Domain 1


(Homo sapiens (Human))
BDBM254914
PNG
(US9493483, 402)
Show SMILES CN(C)C(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(ccc2-c2c(C)noc12)-c1cnn(C)c1
Show InChI InChI=1S/C26H24ClN5O2/c1-15-24-20-10-7-17(18-13-28-32(4)14-18)11-21(20)25(16-5-8-19(27)9-6-16)29-22(26(24)34-30-15)12-23(33)31(2)3/h5-11,13-14,22H,12H2,1-4H3/t22-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 13n/an/an/an/a7.025



Constellation Pharmaceuticals, Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the ...


US Patent US9493483 (2016)


BindingDB Entry DOI: 10.7270/Q26D5RXQ
More data for this
Ligand-Target Pair