BDBM25570 2,6-Disubstituted Pyrazine, 13::4-{6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-yl}benzamide

SMILES COc1cc(Nc2cncc(n2)-c2ccc(cc2)C(N)=O)cc(OC)c1OC

InChI Key InChIKey=LZLKDDDQYGMZTB-UHFFFAOYSA-N

Data  1 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25570   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25570(2,6-Disubstituted Pyrazine, 13 | 4-{6-[(3,4,5-trim...)
Affinity DataIC50:  1.10E+3nMpH: 7.2 T: 22°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed