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BDBM255823 3′-[1-(4-Amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)ethyl]-5′-chloro-2′-methoxy-N,N,6′-trimethylbiphenyl-3-sulfonamide bis(trifluoroacetate)::US10092570, Example 32::US9707233, 32

SMILES: COc1c(cc(Cl)c(C)c1-c1cccc(c1)S(=O)(=O)N(C)C)C(C)n1ccc(=O)c2c(N)ncnc12

InChI Key: InChIKey=GWTTVTZZVDBTMB-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 255823   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM255823
PNG
(3′-[1-(4-Amino-5-oxopyrido[2,3-d]pyrimidin-8...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cccc(c1)S(=O)(=O)N(C)C)C(C)n1ccc(=O)c2c(N)ncnc12
Show InChI InChI=1S/C25H26ClN5O4S/c1-14-19(26)12-18(15(2)31-10-9-20(32)22-24(27)28-13-29-25(22)31)23(35-5)21(14)16-7-6-8-17(11-16)36(33,34)30(3)4/h6-13,15H,1-5H3,(H2,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255823
PNG
(3′-[1-(4-Amino-5-oxopyrido[2,3-d]pyrimidin-8...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cccc(c1)S(=O)(=O)N(C)C)C(C)n1ccc(=O)c2c(N)ncnc12
Show InChI InChI=1S/C25H26ClN5O4S/c1-14-19(26)12-18(15(2)31-10-9-20(32)22-24(27)28-13-29-25(22)31)23(35-5)21(14)16-7-6-8-17(11-16)36(33,34)30(3)4/h6-13,15H,1-5H3,(H2,27,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair