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BDBM255828 6-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-4-chloro-N-ethyl-3′,5′-difluoro-3-methylbiphenyl-2-carboxamide::US10092570, Example 37::US9707233, 37::US9730939, Example 37

SMILES: CCNC(=O)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1-c1cc(F)cc(F)c1

InChI Key: InChIKey=ZXJQEONXJODXNF-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 255828   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
p110delta/p85alpha


(Homo sapiens (Human))
BDBM255828
PNG
(6-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCNC(=O)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1-c1cc(F)cc(F)c1
Show InChI InChI=1S/C24H23ClF2N6O/c1-5-29-24(34)19-11(2)18(25)9-17(21(19)14-6-15(26)8-16(27)7-14)13(4)33-23-20(12(3)32-33)22(28)30-10-31-23/h6-10,13H,5H2,1-4H3,(H,29,34)(H2,28,30,31)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255828
PNG
(6-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCNC(=O)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1-c1cc(F)cc(F)c1
Show InChI InChI=1S/C24H23ClF2N6O/c1-5-29-24(34)19-11(2)18(25)9-17(21(19)14-6-15(26)8-16(27)7-14)13(4)33-23-20(12(3)32-33)22(28)30-10-31-23/h6-10,13H,5H2,1-4H3,(H,29,34)(H2,28,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255828
PNG
(6-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCNC(=O)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1-c1cc(F)cc(F)c1
Show InChI InChI=1S/C24H23ClF2N6O/c1-5-29-24(34)19-11(2)18(25)9-17(21(19)14-6-15(26)8-16(27)7-14)13(4)33-23-20(12(3)32-33)22(28)30-10-31-23/h6-10,13H,5H2,1-4H3,(H,29,34)(H2,28,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair