BDBM256535 US10435361, Example 34::US9481648, 34::US9790174, Example 34

SMILES COCCOCCOCCOc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(C(N)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OC)c1

InChI Key InChIKey=XLMGQVCEWMWIIG-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 256535   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
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US Patent
LigandPNGBDBM256535(US10435361, Example 34 | US9481648, 34 | US9790174...)
Affinity DataIC50:  25nMAssay Description:Method 2: This method follows the same steps as Method 1 above, but utilises a higher concentration of the p38 MAPKα protein (2.5 uL of 200 ng/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
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US Patent
LigandPNGBDBM256535(US10435361, Example 34 | US9481648, 34 | US9790174...)
Affinity DataIC50:  19nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
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US Patent
LigandPNGBDBM256535(US10435361, Example 34 | US9481648, 34 | US9790174...)
Affinity DataIC50:  85nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
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US Patent
LigandPNGBDBM256535(US10435361, Example 34 | US9481648, 34 | US9790174...)
Affinity DataIC50:  9.33E+3nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Respivert

US Patent
LigandPNGBDBM256535(US10435361, Example 34 | US9481648, 34 | US9790174...)
Affinity DataIC50:  25nMAssay Description:The following two assay variants can be used for determination of p38 MAPKα inhibition.Method 1The inhibitory activities of test compounds again...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Respivert

US Patent
LigandPNGBDBM256535(US10435361, Example 34 | US9481648, 34 | US9790174...)
Affinity DataIC50:  19nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Respivert

US Patent
LigandPNGBDBM256535(US10435361, Example 34 | US9481648, 34 | US9790174...)
Affinity DataIC50:  85nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Respivert

US Patent
LigandPNGBDBM256535(US10435361, Example 34 | US9481648, 34 | US9790174...)
Affinity DataIC50:  9.33E+3nMAssay Description:Method 2: This method follows the same steps as Method 1 above, but utilises a shorter period of mixing of the test compound (105 minutes instead of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent