BDBM256861 US10654855, Example 49A::US11236095, Example 49B::US9492453, 49A

SMILES NC1(CCN(CC1)c1ncnc2[nH]ccc12)C(=O)N[C@H](CCCN1CCCCC1)c1ccc(Cl)cc1

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 256861   

TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM256861(US10654855, Example 49A | US11236095, Example 49B ...)
Affinity DataIC50:  3.30nMpH: 7.5 T: 2°CAssay Description:This assay detects inhibitors of AKT1 (PKBα) kinase activity using Caliper LabChip LC3000. The Caliper off-chip incubation mobility shift assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM256861(US10654855, Example 49A | US11236095, Example 49B ...)
Affinity DataIC50:  48nMAssay Description:Following addition of compound or control to the assay plate, 6p1 peptide mix containing 3 μM substrate (5-FAM-GRPRTSSFAEG-CONH2; CRB) and 40 &#...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM256861(US10654855, Example 49A | US11236095, Example 49B ...)
Affinity DataIC50:  3.30nMAssay Description:For Echo dosing the solvent was 100% DMSO. A master plate was prepared with 40 ul of 10 mM stock from our Primary Liquid Store in quadrant 1 of a Lab...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent