BDBM25732 3-adamantan-1-yl-1-cyclohexylurea::CHEMBL242255::US8815951, 192::Urea-based compound, 13

SMILES O=C(NC1CCCCC1)NC12CC3CC(CC(C3)C1)C2

InChI Key InChIKey=VESXWSWSGQONHC-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 25732   

TargetEpoxide hydrolase B(Mycobacterium tuberculosis)
University Of Alberta

LigandPNGBDBM25732(3-adamantan-1-yl-1-cyclohexylurea | CHEMBL242255 |...)
Affinity DataIC50:  130nMpH: 7.0 T: 2°CAssay Description:Enzyme activity was measured by monitoring the appearance of fluorescent product, 6-methoxy-naphthaldehyde (ex@330 nm and em@ 465 nm) on a SpectraMax...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpoxide hydrolase 1(Mus musculus (Mouse))
The Regents Of The University Of California

US Patent
LigandPNGBDBM25732(3-adamantan-1-yl-1-cyclohexylurea | CHEMBL242255 |...)
Affinity DataIC50:  50nMAssay Description:The invention also provide methods for assaying for epoxide hydrolase activity as diagnostic assay to identify individuals at increased risk for hype...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpoxide hydrolase 1(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM25732(3-adamantan-1-yl-1-cyclohexylurea | CHEMBL242255 |...)
Affinity DataIC50:  100nMAssay Description:The invention also provide methods for assaying for epoxide hydrolase activity as diagnostic assay to identify individuals at increased risk for hype...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM25732(3-adamantan-1-yl-1-cyclohexylurea | CHEMBL242255 |...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM25732(3-adamantan-1-yl-1-cyclohexylurea | CHEMBL242255 |...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM25732(3-adamantan-1-yl-1-cyclohexylurea | CHEMBL242255 |...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpoxide hydrolase B(Mycobacterium tuberculosis)
University Of Alberta

LigandPNGBDBM25732(3-adamantan-1-yl-1-cyclohexylurea | CHEMBL242255 |...)
Affinity DataIC50:  130nMAssay Description:Inhibition of Mycobacterium tuberculosis recombinant EphB expressed in Escherichia coli BL21 using CMNPC as substrate after 30 mins by fluorescent as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed