BDBM259895 US10308662, Compound 136::US9505780, 136

SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2csc3c2oc(cc3=O)N2CCOCC2)c1

InChI Key InChIKey=HZSUUWMVTVDYKA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 259895   

TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM259895(US10308662, Compound 136 | US9505780, 136)
Affinity DataIC50:  6.15E+3nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [349-460](Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM259895(US10308662, Compound 136 | US9505780, 136)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [44-167](Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM259895(US10308662, Compound 136 | US9505780, 136)
Affinity DataIC50:  6.15E+3nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [368-440](Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM259895(US10308662, Compound 136 | US9505780, 136)
Affinity DataIC50:  1.26E+3nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent