BDBM260504 US10428074, Example 109::US9527851, 109::US9527851, example 109

SMILES COc1cncc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)c1

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 260504   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM260504(US10428074, Example 109 | US9527851, 109 | US95278...)
Affinity DataIC50:  15nMpH: 7.3 T: 2°CAssay Description:In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM260504(US10428074, Example 109 | US9527851, 109 | US95278...)
Affinity DataIC50:  15nMAssay Description:JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM260504(US10428074, Example 109 | US9527851, 109 | US95278...)
Affinity DataIC50:  15nMpH: 7.3 T: 2°CAssay Description:TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent