BDBM26058 5-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-4-phenyl-4H-1,2,4-triazol-3-ol::BI-83C9

SMILES [O-][N+](=O)c1cnc(Sc2n[nH]c(=O)n2-c2ccccc2)s1

InChI Key InChIKey=VOQPTCIVQMNZQA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 26058   

TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM26058(5-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-4-phenyl-4H...)
Affinity DataIC50:  3.10E+3nMpH: 7.5 T: 2°CAssay Description:Compounds were tested for their ability to inhibit JNK1 phosphorylation of ATF2 in the Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM26058(5-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-4-phenyl-4H...)
Affinity DataIC50:  237nMpH: 7.8 T: 2°CAssay Description:Compound was evaluated for its ability to disrupt the interaction of pepJIP1 with JNK1 by using DELFIA assay. DELFIA is a heterogeneous assay whereby...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed