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BDBM261231 US10092570, Example 254::US9707233, 254

SMILES: CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(=O)OC(C)C)C(C)n1nc(C)c2c(N)ncnc12

InChI Key: InChIKey=YJYZWGGKAAEEJC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 261231   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261231
PNG
(US10092570, Example 254 | US9707233, 254)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(=O)OC(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H28ClN7O3/c1-6-34-21-16(14(5)32-23-19(13(4)30-32)22(27)28-11-29-23)7-18(25)17(8-26)20(21)15-9-31(10-15)24(33)35-12(2)3/h7,11-12,14-15H,6,9-10H2,1-5H3,(H2,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261231
PNG
(US10092570, Example 254 | US9707233, 254)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(=O)OC(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H28ClN7O3/c1-6-34-21-16(14(5)32-23-19(13(4)30-32)22(27)28-11-29-23)7-18(25)17(8-26)20(21)15-9-31(10-15)24(33)35-12(2)3/h7,11-12,14-15H,6,9-10H2,1-5H3,(H2,27,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair