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BDBM261349 N-((1s,4s)-4-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-hexafluoropropan-2-yl)phenyl)-4-((4-fluorophenyl)sulfonyl)cyclohexyl)isonicotinamide::US9708253, 7

SMILES: [#8]\[#7]=[#6]-1\[#6]-[#6]C([#6]-[#6]-1)(c1ccc(cc1)C([#8]-[#6]-c1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1

InChI Key: InChIKey=FOYGYSAQORMSLJ-KWQVAVEISA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 261349   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM261349
PNG
(N-((1s,4s)-4-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1...)
Show SMILES ON=C1CCC(CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H22F9NO4S/c29-19-8-10-21(11-9-19)43(40,41)25(14-12-20(38-39)13-15-25)17-4-6-18(7-5-17)26(27(32,33)34,28(35,36)37)42-16-22-23(30)2-1-3-24(22)31/h1-11,39H,12-16H2/b38-20-
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 112n/an/an/an/an/a25



Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US9708253 (2017)

More data for this
Ligand-Target Pair