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BDBM261460 (1-((1s,4s)-4-(4-fluorophenylsulfonyl)-4-(4-(perfluoropropan-2-yl)phenyl)cyclohexyl)-1 H-1,2,3-triazol-4-yl)(morpholino)methanone::US9708253, 119

SMILES: Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)n1cc(nn1)C(=O)N1CCOCC1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F

InChI Key: InChIKey=OVVYWWGTIYPOBG-IVHGUIJPSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 261460   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM261460
PNG
((1-((1s,4s)-4-(4-fluorophenylsulfonyl)-4-(4-(perfl...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)n1cc(nn1)C(=O)N1CCOCC1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C28H26F8N4O4S/c29-20-5-7-22(8-6-20)45(42,43)25(18-1-3-19(4-2-18)26(30,27(31,32)33)28(34,35)36)11-9-21(10-12-25)40-17-23(37-38-40)24(41)39-13-15-44-16-14-39/h1-8,17,21H,9-16H2/t21-,25+
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 141n/an/an/an/an/a25



Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US9708253 (2017)

More data for this
Ligand-Target Pair