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BDBM261461 1-((1s,4s)-4-(4-fluorophenylsulfonyl)-4-(4-(perfluoropropan-2-yl)phenyl)cyclohexyl)-N-(pyridin-3-yl)-1H-1,2,3-triazole-4-carboxamide::US9708253, 120

SMILES: Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)n1cc(nn1)C(=O)Nc1cccnc1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F

InChI Key: InChIKey=BOUJQESHFSKRJR-HNACLESGSA-N

Data: 1 IC50

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 261461   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM261461
PNG
(1-((1s,4s)-4-(4-fluorophenylsulfonyl)-4-(4-(perflu...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]1(CC[C@@H](CC1)n1cc(nn1)C(=O)Nc1cccnc1)c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C29H23F8N5O3S/c30-20-7-9-23(10-8-20)46(44,45)26(18-3-5-19(6-4-18)27(31,28(32,33)34)29(35,36)37)13-11-22(12-14-26)42-17-24(40-41-42)25(43)39-21-2-1-15-38-16-21/h1-10,15-17,22H,11-14H2,(H,39,43)/t22-,26+
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 917n/an/an/an/an/a25



Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US9708253 (2017)

More data for this
Ligand-Target Pair