BDBM262862 3-(2,3-dihydro-1H-isoindol-5- yl)-2-(1H-tetrazol-5-yl)-6- (trifluoromethyl)benzenesulfon- amide::US9708336, 715

SMILES NS(=O)(=O)c1c(ccc(-c2ccc3CNCc3c2)c1-c1nnn[nH]1)C(F)(F)F

InChI Key InChIKey=UZENRFZKKXIQIV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 262862   

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM262862(3-(2,3-dihydro-1H-isoindol-5- yl)-2-(1H-tetrazol-5...)
Affinity DataIC50:  27.4nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVIM-1 metallo-beta-lactamase(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM262862(3-(2,3-dihydro-1H-isoindol-5- yl)-2-(1H-tetrazol-5...)
Affinity DataIC50:  0.729nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM262862(3-(2,3-dihydro-1H-isoindol-5- yl)-2-(1H-tetrazol-5...)
Affinity DataIC50:  25.3nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent