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BDBM263519 US9556150, i-7::{2-[5-amino-1-(2-methyl-4- phenoxy-phenyl)-1h-pyrazole- 4-carbonyl]-1h-indol-5-yl}- morpholin-4-yl-methanone

SMILES: Cc1cc(Oc2ccccc2)ccc1-n1ncc(C(=O)c2cc3cc(ccc3[nH]2)C(=O)N2CCOCC2)c1N

InChI Key: InChIKey=YGRJCUYPHRTGLV-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 263519   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM263519
PNG
(US9556150, i-7 | {2-[5-amino-1-(2-methyl-4- phenox...)
Show SMILES Cc1cc(Oc2ccccc2)ccc1-n1ncc(C(=O)c2cc3cc(ccc3[nH]2)C(=O)N2CCOCC2)c1N
Show InChI InChI=1S/C30H27N5O4/c1-19-15-23(39-22-5-3-2-4-6-22)8-10-27(19)35-29(31)24(18-32-35)28(36)26-17-21-16-20(7-9-25(21)33-26)30(37)34-11-13-38-14-12-34/h2-10,15-18,33H,11-14,31H2,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.60n/an/an/an/a7.15n/a



Hoffmann-La Roche Inc.; Chugai Pharmaceutical Co.

US Patent


Assay Description
This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluorescenc...


US Patent US9556150 (2017)

More data for this
Ligand-Target Pair