BDBM263932 2-(3-cyclopropyl-5-hydroxy-1H- pyrazol-1-yl)isonicotinic acid::US10173996, Example 2::US9604961, Example 2::US9714230, 2::US9908865, Example 2

SMILES OC(=O)c1ccnc(c1)-n1nc(cc1O)C1CC1

InChI Key InChIKey=WEZPYYZPYXGXHK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 263932   

TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM263932(2-(3-cyclopropyl-5-hydroxy-1H- pyrazol-1-yl)isonic...)
Affinity DataIC50: <100nMAssay Description:The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM263932(2-(3-cyclopropyl-5-hydroxy-1H- pyrazol-1-yl)isonic...)
Affinity DataIC50: <100nMAssay Description:The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 2B(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM263932(2-(3-cyclopropyl-5-hydroxy-1H- pyrazol-1-yl)isonic...)
Affinity DataIC50: <100nMAssay Description:The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM263932(2-(3-cyclopropyl-5-hydroxy-1H- pyrazol-1-yl)isonic...)
Affinity DataIC50:  550nMAssay Description:The ability of test compounds to inhibit the activity of JMJD2A was determined in 38-well plate format under the following reaction conditions: 2 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM263932(2-(3-cyclopropyl-5-hydroxy-1H- pyrazol-1-yl)isonic...)
Affinity DataIC50:  550nMAssay Description:The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent