BDBM263953 2-(5-(3-hydroxy-4-methylphenyl)- 1H-pyrazol-1-yl)isonicotinic acid::US10173996, Example 21::US9604961, Example 21::US9714230, 21::US9908865, Example 21

SMILES Cc1ccc(cc1O)-c1ccnn1-c1cc(ccn1)C(O)=O

InChI Key InChIKey=FJCLAYNTNLSCOL-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 263953   

TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM263953(2-(5-(3-hydroxy-4-methylphenyl)- 1H-pyrazol-1-yl)i...)
Affinity DataIC50: <100nMAssay Description:The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM263953(2-(5-(3-hydroxy-4-methylphenyl)- 1H-pyrazol-1-yl)i...)
Affinity DataIC50: <100nMAssay Description:The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM263953(2-(5-(3-hydroxy-4-methylphenyl)- 1H-pyrazol-1-yl)i...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of KDM4C (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM263953(2-(5-(3-hydroxy-4-methylphenyl)- 1H-pyrazol-1-yl)i...)
Affinity DataIC50:  76nMAssay Description:Inhibition of KDM5B (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM263953(2-(5-(3-hydroxy-4-methylphenyl)- 1H-pyrazol-1-yl)i...)
Affinity DataIC50:  550nMAssay Description:The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent