BDBM264164 (E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(cyclopropylmethoxy)quinazolin-6-yl)-4-(2-(hydroxymethyl)azetidin-1-yl)but-2-enamide::US9714235, 8

SMILES OCC1CCN1C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCC1CC1

InChI Key InChIKey=GUHJZZKAWYPNAQ-OWOJBTEDSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 264164   

TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Fochon Pharmaceutical

US Patent
LigandPNGBDBM264164((E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(cyclopr...)
Affinity DataIC50:  11.8nMAssay Description:To investigate whether a compound is able to inhibit the activity of EGFR and ErbB2 in cells, a mechanism-based assay using BT474 (EGFR overexpressio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Fochon Pharmaceutical

US Patent
LigandPNGBDBM264164((E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(cyclopr...)
Affinity DataIC50:  9.5nMAssay Description:To investigate whether a compound is able to inhibit the activity of EGFR and ErbB2 in cells, a mechanism-based assay using BT474 (EGFR overexpressio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent