BDBM26431 (2R)-2-aminopentanedioic acid::CHEMBL76232::D-Glu::D-Glutamate::D-[14C]Glu
SMILES N[C@H](CCC(O)=O)C(O)=O
InChI Key InChIKey=WHUUTDBJXJRKMK-GSVOUGTGSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 52 hits for monomerid = 26431
Affinity DataKi: 340nMAssay Description:Binding affinity at Metabotropic glutamate receptor 1More data for this Ligand-Target Pair
Affinity DataKi: 701nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 750nMAssay Description:Ability of the compound to bind to Ionotropic glutamate receptor kainate (kainate 2) was evaluated.More data for this Ligand-Target Pair
Affinity DataKi: 789nMAssay Description:Ability of the compound to bind to Ionotropic glutamate receptor ionotropic kainate 3 was evaluatedMore data for this Ligand-Target Pair
Affinity DataKi: 868nMAssay Description:Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 4 in HEK293 cells using [3H]-AMPA as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 940nMAssay Description:Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 2 in HK293 cells using [3H]-AMPA as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 1.11E+3nMAssay Description:Binding affinity against human GluR6More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Parc Club Orsay Universit£
Curated by ChEMBL
Parc Club Orsay Universit£
Curated by ChEMBL
Affinity DataKi: 1.20E+3nMAssay Description:Binding affinity at Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
Affinity DataKi: 1.36E+3nMAssay Description:Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 1 in HEK293 cells using [3H]-AMPA as radioligandMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Parc Club Orsay Universit£
Curated by ChEMBL
Parc Club Orsay Universit£
Curated by ChEMBL
Affinity DataKi: 1.60E+3nMAssay Description:Binding affinity at Metabotropic glutamate receptor 4More data for this Ligand-Target Pair
Affinity DataKi: 3.28E+3nMAssay Description:Displacement of [3H]kainate from rat GLUK6 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 3.28E+3nMAssay Description:Displacement of [3H]kainate from rat GLUK6 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetGlutamate racemase(Helicobacter pylori)
Astrazeneca Global Structural Chemistry
Curated by ChEMBL
Astrazeneca Global Structural Chemistry
Curated by ChEMBL
Affinity DataKi: 5.80E+3nMAssay Description:Inhibition of Helicobacter pylori glutamate racemaseMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 5.60E+4nMAssay Description:Compound was evaluated for in vitro functional inhibitory potency for prevention of sarafotoxin S6c induced constriction of rat tracheal rings (ETB r...More data for this Ligand-Target Pair
Affinity DataKi: 1.90E+5nMAssay Description:Inhibition towards glutamate racemase was determined and expressed as KIMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at rat mGluR7 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 8.22E+4nMAssay Description:Agonist activity at rat mGluR6 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.26E+4nMAssay Description:Agonist activity at rat mGluR4 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+4nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 1More data for this Ligand-Target Pair
Affinity DataEC50: 1.20E+4nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 4More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Parc Club Orsay Universit£
Curated by ChEMBL
Parc Club Orsay Universit£
Curated by ChEMBL
Affinity DataEC50: 4.00E+3nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
The Royal Danish School Of Pharmacy
Curated by ChEMBL
The Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 4.40E+3nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 5More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Parc Club Orsay Universit£
Curated by ChEMBL
Parc Club Orsay Universit£
Curated by ChEMBL
Affinity DataEC50: 1.83E+4nMAssay Description:Agonist activity at rat mGluR2 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.20E+4nMAssay Description:Induction of calcium influx in HEK293 cells expressing human GLUK5 by FLIPR assayMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataEC50: 3.10E+3nMAssay Description:Compound was tested for the inhibition of Metabotropic glutamate receptor 5More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 6(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataEC50: 4.90E+3nMAssay Description:Compound was tested for the inhibition of Metabotropic glutamate receptor 6More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Parc Club Orsay Universit£
Curated by ChEMBL
Parc Club Orsay Universit£
Curated by ChEMBL
Affinity DataEC50: 290nMAssay Description:Compound was tested for the inhibition of metabotropic glutamate receptor 2 (mGluR2).More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataEC50: 4.90E+3nMAssay Description:Compound was tested for the inhibition of Metabotropic glutamate receptor 1More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Parc Club Orsay Universit£
Curated by ChEMBL
Parc Club Orsay Universit£
Curated by ChEMBL
Affinity DataEC50: 9.80E+3nMAssay Description:Compound was tested for the inhibition of Metabotropic glutamate receptor 4More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataEC50: >1.00E+6nMAssay Description:Agonistic activity at mGlu1-alpha receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 6(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataEC50: >1.00E+6nMAssay Description:Agonistic activity at mGlu6 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Parc Club Orsay Universit£
Curated by ChEMBL
Parc Club Orsay Universit£
Curated by ChEMBL
Affinity DataEC50: >1.00E+6nMAssay Description:Agonistic activity at mGlu2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20E+4nMAssay Description:Effect on Metabotropic glutamate receptor 4More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Parc Club Orsay Universit£
Curated by ChEMBL
Parc Club Orsay Universit£
Curated by ChEMBL
Affinity DataEC50: 4.00E+3nMAssay Description:Effect on Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+4nMAssay Description:Effect on Metabotropic glutamate receptor 1More data for this Ligand-Target Pair
Affinity DataEC50: 5.40E+6nMAssay Description:Effect on Metabotropic glutamate receptor 7More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
The Royal Danish School Of Pharmacy
Curated by ChEMBL
The Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 4.40E+3nMAssay Description:Effect on Metabotropic glutamate receptor 5More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Royal Danish School Of Pharmacy
Curated by ChEMBL
Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 9.00E+3nMAssay Description:Effect on Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
Affinity DataEC50: 2.00E+4nMAssay Description:Effect on Metabotropic glutamate receptor 6More data for this Ligand-Target Pair
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as in...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Parc Club Orsay Universit£
Curated by ChEMBL
Parc Club Orsay Universit£
Curated by ChEMBL
Affinity DataEC50: 1.26E+4nMAssay Description:Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataEC50: 6.31E+5nMAssay Description:Agonist activity at recombinant GluR5More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 6(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataEC50: 2.70E+5nMAssay Description:Agonist activity at recombinant GluR6More data for this Ligand-Target Pair
Affinity DataEC50: 2.88E+3nMAssay Description:Agonist activity at rat mGlu4 receptor expressed in HEK293 cells coexpressing Gq/Gi and EAAC1 assessed as intracellular calcium production measured e...More data for this Ligand-Target Pair
Affinity DataEC50: 2.15E+4nMAssay Description:Agonist activity at rat mGluR8 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.32E+4nMAssay Description:Agonist activity at rat mGluR1 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.50E+4nMAssay Description:Effective concentration against human GluR6 expressed in HEK293 cellsMore data for this Ligand-Target Pair