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BDBM264730 2-(5-tert-Butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-4-methoxy-6- (2-trifluoromethoxy-phenyl)-3H-imidazo[4,5-c]pyridine::US9718820, Compound 2

SMILES: COc1nc(cc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F

InChI Key: InChIKey=NWHYESYIRRYBBK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 264730   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM264730
PNG
(2-(5-tert-Butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)...)
Show SMILES COc1nc(cc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C22H21ClF3N5O/c1-21(2,3)18-15(23)17(31(4)30-18)19-27-14-10-13(28-20(32-5)16(14)29-19)11-8-6-7-9-12(11)22(24,25)26/h6-10H,1-5H3,(H,27,29)
KEGG

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/an/a25



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, ...


US Patent US9718820 (2017)

More data for this
Ligand-Target Pair