BDBM26573 (3R,4R)-3-N-hydroxy-4-N-(4-{[2-(propan-2-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}benzene)oxane-3,4-dicarboxamide::pyrazolopyridine, 47

SMILES CC(C)c1nn2ccccc2c1Cc1ccc(cc1)C(=O)N[C@@H]1CCOC[C@@H]1C(=O)NO

InChI Key InChIKey=FLPIBFXJTDQPCO-VQTJNVASSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 26573   

TargetMacrophage metalloelastase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26573((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(propan-2-yl)pyrazo...)
Affinity DataKi:  119nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26573((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(propan-2-yl)pyrazo...)
Affinity DataKi:  2.65E+3nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26573((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(propan-2-yl)pyrazo...)
Affinity DataKi:  3.31E+3nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26573((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(propan-2-yl)pyrazo...)
Affinity DataKi: >3.33E+3nM ΔG°: >-7.47kcal/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
Bristol-Myers Squibb

LigandPNGBDBM26573((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(propan-2-yl)pyrazo...)
Affinity DataIC50:  1.70nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed