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BDBM266501 US9718822, 2

SMILES: O=C1NCCCOc2cccc(n2)[C@H]2CCCN2c2ccn3ncc1c3n2

InChI Key: InChIKey=ZBXKQGMXXMNDQF-OAHLLOKOSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 266501   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM266501
PNG
(US9718822, 2)
Show SMILES O=C1NCCCOc2cccc(n2)[C@H]2CCCN2c2ccn3ncc1c3n2
Show InChI InChI=1S/C19H20N6O2/c26-19-13-12-21-25-10-7-16(23-18(13)25)24-9-2-5-15(24)14-4-1-6-17(22-14)27-11-3-8-20-19/h1,4,6-7,10,12,15H,2-3,5,8-9,11H2,(H,20,26)/t15-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/a7.5n/a



Array BioPharma, Inc.

US Patent


Assay Description
The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen¿ Eu Kinase Binding Assay. In this assay, His-tagged recombina...


US Patent US9718822 (2017)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM266501
PNG
(US9718822, 2)
Show SMILES O=C1NCCCOc2cccc(n2)[C@H]2CCCN2c2ccn3ncc1c3n2
Show InChI InChI=1S/C19H20N6O2/c26-19-13-12-21-25-10-7-16(23-18(13)25)24-9-2-5-15(24)14-4-1-6-17(22-14)27-11-3-8-20-19/h1,4,6-7,10,12,15H,2-3,5,8-9,11H2,(H,20,26)/t15-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/a7.5n/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9718822 (2017)

More data for this
Ligand-Target Pair