BDBM26660 3,7-dihydroxy-2-phenyl-4H-chromen-4-one::3,7-dihydroxyflavone::CHEMBL210276

SMILES Oc1ccc2c(c1)oc(-c1ccccc1)c(O)c2=O

InChI Key InChIKey=UWQJWDYDYIJWKY-UHFFFAOYSA-N

Data  10 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 26660   

TargetSerine/threonine-protein kinase pim-1(Human)
Loma Linda University

LigandPNGBDBM26660(3,7-dihydroxy-2-phenyl-4H-chromen-4-one | 3,7-dihy...)
Affinity DataIC50:  4.60E+3nMpH: 7.0 T: 30°CAssay Description:The 96-well flat-bottomed plates were coated with recombinant GST-BAD. After the plates were blocked, the reaction buffer containing test compound an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 3(Human)
Josip Juraj Strossmayer University of Osijek

LigandPNGBDBM26660(3,7-dihydroxy-2-phenyl-4H-chromen-4-one | 3,7-dihy...)
Affinity DataIC50:  9.80E+4nMpH: 7.4 T: 37°CAssay Description:The inhibitory activity of flavonoids toward human DPP III was assayed in a 50 mM Tris-HCl buffer, pH 7.4. In brief, recombinant human DPP III (0.29 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Loma Linda University

LigandPNGBDBM26660(3,7-dihydroxy-2-phenyl-4H-chromen-4-one | 3,7-dihy...)
Affinity DataIC50:  4.57E+3nMAssay Description:Inhibition of PIM1 kinaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
Universidad De Santiago De Chile

Curated by ChEMBL
LigandPNGBDBM26660(3,7-dihydroxy-2-phenyl-4H-chromen-4-one | 3,7-dihy...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 15-hLO2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM26660(3,7-dihydroxy-2-phenyl-4H-chromen-4-one | 3,7-dihy...)
Affinity DataIC50:  1.25E+7nMAssay Description:Inhibition of P-gp in human HK2 cells assessed as Rhodamine-123 accumulation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
Universidad De Santiago De Chile

Curated by ChEMBL
LigandPNGBDBM26660(3,7-dihydroxy-2-phenyl-4H-chromen-4-one | 3,7-dihy...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 12-hLOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Human)
Institut De Recerca BiomèDica De Barcelona

Curated by ChEMBL
LigandPNGBDBM26660(3,7-dihydroxy-2-phenyl-4H-chromen-4-one | 3,7-dihy...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human brain prolyl oligopeptidase expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Human)
Institut De Recerca BiomèDica De Barcelona

Curated by ChEMBL
LigandPNGBDBM26660(3,7-dihydroxy-2-phenyl-4H-chromen-4-one | 3,7-dihy...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM26660(3,7-dihydroxy-2-phenyl-4H-chromen-4-one | 3,7-dihy...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of FabIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Universidad De Santiago De Chile

Curated by ChEMBL
LigandPNGBDBM26660(3,7-dihydroxy-2-phenyl-4H-chromen-4-one | 3,7-dihy...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 15-hLO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed