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BDBM267141 N-{2-[4-(benzyloxy)piperidin-1-yl]-2-(1,3-thiazol-5-yl)ethyl}-2-chloro-6-fluorobenzamide::US10167281, Compound 25::US9718812, 25

SMILES: Fc1cccc(Cl)c1C(=O)NCC(N1CCC(CC1)OCc1ccccc1)c1cncs1

InChI Key: InChIKey=IOSVWCFPRWFMJJ-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 267141   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267141
PNG
(N-{2-[4-(benzyloxy)piperidin-1-yl]-2-(1,3-thiazol-...)
Show SMILES Fc1cccc(Cl)c1C(=O)NCC(N1CCC(CC1)OCc1ccccc1)c1cncs1
Show InChI InChI=1S/C24H25ClFN3O2S/c25-19-7-4-8-20(26)23(19)24(30)28-13-21(22-14-27-16-32-22)29-11-9-18(10-12-29)31-15-17-5-2-1-3-6-17/h1-8,14,16,18,21H,9-13,15H2,(H,28,30)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 48n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US9718812 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267141
PNG
(N-{2-[4-(benzyloxy)piperidin-1-yl]-2-(1,3-thiazol-...)
Show SMILES Fc1cccc(Cl)c1C(=O)NCC(N1CCC(CC1)OCc1ccccc1)c1cncs1
Show InChI InChI=1S/C24H25ClFN3O2S/c25-19-7-4-8-20(26)23(19)24(30)28-13-21(22-14-27-16-32-22)29-11-9-18(10-12-29)31-15-17-5-2-1-3-6-17/h1-8,14,16,18,21H,9-13,15H2,(H,28,30)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 42n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267141
PNG
(N-{2-[4-(benzyloxy)piperidin-1-yl]-2-(1,3-thiazol-...)
Show SMILES Fc1cccc(Cl)c1C(=O)NCC(N1CCC(CC1)OCc1ccccc1)c1cncs1
Show InChI InChI=1S/C24H25ClFN3O2S/c25-19-7-4-8-20(26)23(19)24(30)28-13-21(22-14-27-16-32-22)29-11-9-18(10-12-29)31-15-17-5-2-1-3-6-17/h1-8,14,16,18,21H,9-13,15H2,(H,28,30)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 48n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267141
PNG
(N-{2-[4-(benzyloxy)piperidin-1-yl]-2-(1,3-thiazol-...)
Show SMILES Fc1cccc(Cl)c1C(=O)NCC(N1CCC(CC1)OCc1ccccc1)c1cncs1
Show InChI InChI=1S/C24H25ClFN3O2S/c25-19-7-4-8-20(26)23(19)24(30)28-13-21(22-14-27-16-32-22)29-11-9-18(10-12-29)31-15-17-5-2-1-3-6-17/h1-8,14,16,18,21H,9-13,15H2,(H,28,30)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 42n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...


US Patent US9718812 (2017)

More data for this
Ligand-Target Pair