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BDBM267270 3-chloro-5-((1-((5-(5- chloro-2- fluorophenyl)-6-oxo- 1,6-dihydropyridazin- 3-yl)methyl)-6-oxo- 4-(trifluoromethyl)- 1,6- dihydropyrimidin-5- yl)oxy)benzonitrile::US9718819, 47

SMILES: Fc1ccc(Cl)cc1-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O

InChI Key: InChIKey=PQJSBROQAJCJIN-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 267270   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267270
PNG
(3-chloro-5-((1-((5-(5- chloro-2- fluorophenyl)-6-o...)
Show SMILES Fc1ccc(Cl)cc1-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C23H11Cl2F4N5O3/c24-12-1-2-18(26)16(6-12)17-7-14(32-33-21(17)35)9-34-10-31-20(23(27,28)29)19(22(34)36)37-15-4-11(8-30)3-13(25)5-15/h1-7,10H,9H2,(H,33,35)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 11n/an/an/an/a7.825



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair