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BDBM267289 3-chloro-5-((1-((5- cyclopropyl-6-oxo- 1,6-dihydropyridazin- 3-yl)methyl)-6-oxo- 4-(trifluoromethyl)- 1,6- dihydropyrimidin-5- yl)oxy)benzonitrile::US9718819, 66

SMILES: FC(F)(F)c1ncn(Cc2cc(C3CC3)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N

InChI Key: InChIKey=XPVMGHIKFWHSSX-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 267289   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267289
PNG
(3-chloro-5-((1-((5- cyclopropyl-6-oxo- 1,6-dihydro...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(C3CC3)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C20H13ClF3N5O3/c21-12-3-10(7-25)4-14(5-12)32-16-17(20(22,23)24)26-9-29(19(16)31)8-13-6-15(11-1-2-11)18(30)28-27-13/h3-6,9,11H,1-2,8H2,(H,28,30)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 7n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair