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BDBM267298 3-chloro-5-((1-((5-(4- cyanophenyl)-6-oxo- 1,6-dihydropyridazin- 3-yl)methyl)-6-oxo- 4-(trifluoromethyl)- 1,6- dihydropyrimidin-5- yl)oxy)benzonitrile::US9718819, 75

SMILES: FC(F)(F)c1ncn(Cc2cc(-c3ccc(cc3)C#N)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N

InChI Key: InChIKey=JXHOQHWHDXTAHB-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 267298   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267298
PNG
(3-chloro-5-((1-((5-(4- cyanophenyl)-6-oxo- 1,6-dih...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(-c3ccc(cc3)C#N)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C24H12ClF3N6O3/c25-16-5-14(10-30)6-18(7-16)37-20-21(24(26,27)28)31-12-34(23(20)36)11-17-8-19(22(35)33-32-17)15-3-1-13(9-29)2-4-15/h1-8,12H,11H2,(H,33,35)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair