BindingDB logo
myBDB logout

BDBM267304 3-chloro-5-((6-oxo-1-((6- oxo-5-(pyridin-4-yl)-1,6- dihydropyridazin-3- yl)methyl)-4- (trifluoromethyl)-1,6- dihydropyrimidin-5- yl)oxy)benzonitrile::US9718819, 81

SMILES: FC(F)(F)c1ncn(Cc2cc(-c3ccncc3)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N

InChI Key: InChIKey=ZBNSKAZQTZEATI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 267304   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267304
PNG
(3-chloro-5-((6-oxo-1-((6- oxo-5-(pyridin-4-yl)-1,6...)
Show SMILES FC(F)(F)c1ncn(Cc2cc(-c3ccncc3)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C22H12ClF3N6O3/c23-14-5-12(9-27)6-16(7-14)35-18-19(22(24,25)26)29-11-32(21(18)34)10-15-8-17(20(33)31-30-15)13-1-3-28-4-2-13/h1-8,11H,10H2,(H,31,33)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 9n/an/an/an/a7.825



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair