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BDBM267337 3-chloro-5-((1-((6- (3-fluorophenyl)-3- oxo-2,3- dihydropyridazin-4- yl)methyl)-6-oxo-4- (trifluoromethyl)- 1,6- dihydropyrimidin- 5- yl)oxy)benzonitrile::US9718819, 113

SMILES: Fc1cccc(c1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]n1

InChI Key: InChIKey=SUSXXAFBRXWDBE-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 267337   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267337
PNG
(3-chloro-5-((1-((6- (3-fluorophenyl)-3- oxo-2,3- d...)
Show SMILES Fc1cccc(c1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]n1
Show InChI InChI=1S/C23H12ClF4N5O3/c24-15-4-12(9-29)5-17(8-15)36-19-20(23(26,27)28)30-11-33(22(19)35)10-14-7-18(31-32-21(14)34)13-2-1-3-16(25)6-13/h1-8,11H,10H2,(H,32,34)
PDB
MMDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/a7.825



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair