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BDBM267346 4-(5-((5-(3-chloro- 5-cyanophenoxy)- 6-oxo-4- (trifluoromethyl) pyrimidin-1(6H)- yl)methyl)-6-oxo- 1,6- dihydropyridazin-3- yl)-2- fluorobenzonitrile::US9718819, 122

SMILES: Fc1cc(ccc1C#N)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]n1

InChI Key: InChIKey=MYIMVDTWYPRMIZ-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 267346   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267346
PNG
(4-(5-((5-(3-chloro- 5-cyanophenoxy)- 6-oxo-4- (tri...)
Show SMILES Fc1cc(ccc1C#N)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]n1
Show InChI InChI=1S/C24H11ClF4N6O3/c25-16-3-12(8-30)4-17(7-16)38-20-21(24(27,28)29)32-11-35(23(20)37)10-15-6-19(33-34-22(15)36)13-1-2-14(9-31)18(26)5-13/h1-7,11H,10H2,(H,34,36)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/a7.825



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)

More data for this
Ligand-Target Pair