BDBM26808 (7S,8R)-7-N-hydroxy-8-N-{4-[(2-methylquinolin-4-yl)methoxy]benzene}-1,4-dioxaspiro[4.4]nonane-7,8-diamido::1,3-dioxolane beta-amino hydroxamate , 1

SMILES Cc1cc(COc2ccc(cc2)C(=O)N[C@@H]2C[C@@]3(C[C@@H]2C(=O)NO)OCCO3)c2ccccc2n1

InChI Key InChIKey=KRGIXMSVPSMLII-JTHBVZDNSA-N

Data  6 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 26808   

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26808((7S,8R)-7-N-hydroxy-8-N-{4-[(2-methylquinolin-4-yl...)
Affinity DataKi: >2.13E+3nM ΔG°: >-7.73kcal/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26808((7S,8R)-7-N-hydroxy-8-N-{4-[(2-methylquinolin-4-yl...)
Affinity DataKi: >2.13E+3nMAssay Description:Binding affinity to MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26808((7S,8R)-7-N-hydroxy-8-N-{4-[(2-methylquinolin-4-yl...)
Affinity DataKi:  2.80E+3nM ΔG°:  -7.57kcal/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26808((7S,8R)-7-N-hydroxy-8-N-{4-[(2-methylquinolin-4-yl...)
Affinity DataKi:  2.80E+3nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM26808((7S,8R)-7-N-hydroxy-8-N-{4-[(2-methylquinolin-4-yl...)
Affinity DataKi: >4.95E+3nMAssay Description:Binding affinity to MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM26808((7S,8R)-7-N-hydroxy-8-N-{4-[(2-methylquinolin-4-yl...)
Affinity DataKi: >4.95E+3nM ΔG°: >-7.23kcal/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM26808((7S,8R)-7-N-hydroxy-8-N-{4-[(2-methylquinolin-4-yl...)
Affinity DataIC50:  1nMAssay Description:Inhibition of pig TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM26808((7S,8R)-7-N-hydroxy-8-N-{4-[(2-methylquinolin-4-yl...)
Affinity DataIC50:  1nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed