BDBM26888 8-(diphenylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one::CHEMBL240657::spiropiperidine analogue, 9

SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C(c1ccccc1)c1ccccc1

InChI Key InChIKey=MLVHNSLPGKIYBU-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 26888   

TargetNociceptin receptor(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26888(8-(diphenylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]...)
Affinity DataKi:  23nM ΔG°:  -10.3kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26888(8-(diphenylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]...)
Affinity DataKi:  23nMAssay Description:Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26888(8-(diphenylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]...)
Affinity DataKi:  137nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26888(8-(diphenylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]...)
Affinity DataKi:  137nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM26888(8-(diphenylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]...)
Affinity DataKi:  486nMAssay Description:Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM26888(8-(diphenylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]...)
Affinity DataKi:  489nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26888(8-(diphenylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]...)
Affinity DataKi:  3.79E+4nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26888(8-(diphenylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]...)
Affinity DataKi:  3.79E+4nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed